Issue : 01 DOI : 10.5281/zenodo.8147277
INTERNATIONAL
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Abstract
Although there is much advancement in its understanding, cancer is still one among the leading causes of death. . People from
every corner of world are having some health problems due to environmental pollution, which leads to oxidative stress. Changed
lifestyle is also one of the greatest cause of oxidative stress. Oxidative stress in body increases and we start cellular aging. Many
factors are associated for causing the cancer. It may be caused either by external or internal factors or both. Consumption of
tobacco and alcohol, exposure to hazardous chemicals, ionizing radiation, infectious organisms, and other lifestyle factors comes
in external factors, whereas internal factors include inherited mutations, an imbalanced hormone level, and poor immune
conditions. This affect the incidence and mortality of cancer by modifying cellular systems of the organism. Internal factors such
as hereditary mutation cannot be modified. Lifestyle and environmental factors are the external factors which need to be modified
to control the incidence of cancer. Silent course of pathogenesis of cancer leads to poor prognosis. Early diagnosis therefore is
very essential from the prognostic point of view for cancer. Looking at the pervasive nature of cancer, this may be hypothesized
that the cause of cancer must be related closely to our lifestyles and environmental exposures. Ayurveda, an ancient health-care
wisdom presents its own principles to understand the cause of disease and health. One can choose to remain healthy by following
the recommended path for healthy living and even can revert to health. This review presents a comprehensive view of general
principles of health proposed by Ayurveda and attempts to see their applicability in the field of cancer prevention.
Keywords: Cancer, Ayurveda, oxidative stress, lifestyle, mutation, ionizing
Corresponding author: Dr. Pradnya Dakhole
Article Info: Published on : 15/04/2024
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INTERNATIONAL JOURNAL OF DIAGNOSTICS AND RESEARCH
Preventive Measures of Cancer in Ayurveda : A Review
Dr. Pradnya Dakhole
1
, Dr. Charuta Parlewar
2
, Dr. Sheetal Asutkar
3
1
Professor& Head Dept. of Shalya Tantra Smt. Shalinitai Meghe Ayurved College, Hospital &RC, Bhilewada, Bhandara.
2
Associate Professor & Head, Dept. of Samhita Siddhant, Shri Gurudev Ayurved College and Hospital, Mozari.
3
Professor and Head, Dept. of Shalya Tantra DMIM’S, MGACH&RC, Salod, Wardha.
Cite this article as: - Dr. Pradnya Dakhole (2024) ; Preventive measures of cancer in Ayurveda : A Review ; Inter.J.Dignostics and
Research 1(3) 1-6,DOI :10.5281/zenedo.10972407
Introduction:
According to World Health Organization Health is
a state of complete physical, mental and social
well- being and not merely an absence of disease or
infirmity." Later the ability to lead a "socially and
economically productive life" was added to it
[1]
.
One of the leading causes of death around the world
is Cancer. Although modern science is quiet
successful in understanding cancer and its
molecular basis, the knowledge about preventing or
treating cancer completely is still unknown. Factors
that are associated with the causation of cancer may
be external factors, internal factors or both.
Consumption of tobacco and alcohol, exposure to
hazardous chemicals, ionizing radiation, infectious
organisms, and other lifestyle factors are external
factors, whereas internal factors are inherited
mutations, an imbalanced hormone level, and poor
immune conditions
[2]
. They affect the incidence
and mortality of cancer by modifying cellular
systems of the organism. Internal factors like
hereditary mutation cannot be modified. To control
G
A
R
V
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cancer, external factors such as lifestyle and
environmental factors need to be modified. To
achieve this one should cease smoking, minimal use
of alcohol, increase consumption of fruits,
vegetables and whole grains, physical activity,
avoid direct exposure to sunlight, consume minimal
red meat , execute proper vaccinations and routine
screening. Oxidative stress, caused by the
overproduction of free radicals, leads to the
development of many chronic diseases including
cancer
[3]
. It has been shown that adopting changes
in lifestyle can reduce over 90% of cancer
incidence
[4]
. Although cancer is understood much
better today still, the search for an ideal treatment
that has minimal side effects and is cost-effective
continues. It is still a major health issue that
burdens high care cost and causes physical and
emotional difficulties to cancer patients. Besides
preventive measures, several therapeutic modalities
like chemotherapy, radiotherapy and surgical
treatment have been developed. Though they are
very effective but very expensive treatment
measures and cause serious side effects. Many
times, patients develop resistance to the therapy
[5]
.
Poor prognosis of cancer is primarily attributed to
its silent course of pathogenesis. In prognostic point
of view early diagnosis in cancer is very crucial.
Looking at the pervasive nature of cancer, this may
be hypothesized that the cause of cancer must be
related closely to our lifestyles and environmental
exposures. Ayurveda, an ancient health-care
wisdom presents its own principles to understand
the cause of disease and health. To remain healthy,
one should follow the recommended right path for
healthy living. This review presents a
comprehensive view of general principles of health
proposed by Ayurveda and attempts to see their
applicability in the field of cancer prevention.
Aim : To evaluate the preventive measures of
cancer according to Ayurveda.
Objectives-
1. To evaluate causes of cancers.
2. To evaluate preventive measures of cancer
according to causes in Ayurveda.
Material and Method :
All the literature from classical texts of Ayurveda,
viz, Charak Samhita, Sushruta Samhita and
Ashtang Hriday with their respective commentaries
were reviewed. Modern medicine books were
referred for modern perspective. The information
from various search engines and journals.
Discussion :
Ayurveda is an ancient science of life. It has two
important domains known as Swasthavritta and
Aturavritta. The main cause of disease is
considered to be Mandagni (diminished digestive
power). Recent researches have shown that lifestyle
modifications suppress down the occurrence of
Mandagni related disorders
[6]
. Ayurvedic treatise
are enriched with numerous preventive measures,
curative medicines and procedures as well. Many
researches are going in different fields of Ayurveda
such as Rasayana, Panchakarma etc., for
establishing their action in all fields of therapeutics.
It is the only known system of medicine across the
world which believes the need of regular
purification of the human biological system from
gross level to the molecular level to render it
suitable for self-recovery and therapeutic
responsiveness. The key principle followed in the
Ayurveda is “Swasthasya Swasthya Rakshanam”,
which means to maintain the health of the healthy,
rather than “Aturasya Vikara Prashamanamcha”,
means to cure the diseases of the diseased
[7]
.
Dinacharya (daily regimen) and Ritucharya
(seasonal regimen) have been mentioned for this
purpose in the classics of Ayurveda
[8]
. Applying
the knowledge of Ritucharya we can surely avoid
these by practicing regimen in accordance with the
Ritu (seasons) to maintain the harmony of the
Tridosha and to stay healthy ever. It is now evident
that ancient techniques, therapeutics (Rasayana),
Panchakarma and Yoga etc are being accepted to
accomplish the following goals of treatment :
1.Strengthen immune system.
2.Efficient detoxification system.
3.Responsive inflammatory system.
4.Optimal metabolic system.
5.Balanced regulatory system.
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6.Enhanced regenerative system.
7.Harmonize the life force.
8. Free radical scavenging or anti-oxidant
[9]
.
9.Consumption of tobacco and alcohol depends on
our mind, which we can call as Mansikvega and for
Dharan of Mansikvega ( mind control), person
should be aware of code and conduct ( Sadvritta)
mentioned by Ayurveda
[10]
. Human being is
constantly in search of happiness and there is no
happiness without righteousness. Hence all should
follow the path of righteousness. The rule of good
conduct, he who adapts it will attain long life,
health, wealth, reputation & also the eternal world
[11]
.
10.The code of conduct mentioned in Ayurveda is
in accordance to that era and the problems of today
need to develop new code of conduct so that we can
prevent diseases occurring due to exposure to
hazardous chemicals, ionizing radiations due to
occupation, also the pollution & changes in
environment, loss of ozone layer in atmosphere.
11.According to Ayurveda infection is not primary
cause of any disease. Occurrence of disease
depends on our immune system and not on
organism
[12]
immune system means presence of
Oja’ in proper level in body. Oja provides strength
to body in terms of physical, mental,
immunological and resistance of body
[13]
.
12.To strengthen the immunity Oja should be in it
limits, Ayurveda states if the metabolism of dhatu is
good the Oja produced is supreme as Oja is Prasad
Bhag of Dhatu . Regular exercise and work out
(Vividhascha Chesta) and healthy diet
Pathyakarahar) is must for good immunity
[14]
. The
causes of cancer are both infections and low
immune system will over by regular exercise and
healthy diet. To strengthen Oja, herbs of Jivaniya
Gan, milk and Mansa Ras has to be taken in regular
diet
[15]
.
13.Oxidative stress is a crucial factor in the
development of chronic diseases including cancer.
Antioxidants are thus required to counteract
oxidative stress and overcome cellular damage for
the prevention of oxidative stress related diseases
like cancer. The antioxidants can be produced by
cells endogenously or can be supplied to the cells
through food or exogenously
[16]
. Because of the
limitations in endogenous productions of
antioxidants by cells, exogenous supplements of
antioxidants can satisfy the requirement and thereby
reduce oxidative stress mediated cellular damage
and carcinogenesis
[17]
. According to one study
Ayurvedic medicine Jeevaneeya Rasayan" ( an
Ayurvedic polyherb formulation ) was found to
increase the anti oxidant enzymes and level of
glutathione content in arthritic rats. This
formulation also decreased the concentration of C-
reactive protein, thiobarbituric acid reactive
substances and ceruloplasmin in rats
[18]
. Means it
acts like anti inflammatory.
14.Hormonal imbalance hormones create
emotions of Sukh ( happiness ) and Dukh ( sadness
). If one follows the guidelines of code of conduct
like exercising regularly, managing stress, getting
enough quality sleep, quitting smoking or using
tobacco products, having healthy food and
maintaining healthy weight, it will give good health
resulting in production of good balanced hormones.
Yoga and meditation also helps in hormone
regulation. Yoga has been shown to stabilize
emotional imbalances, prevent the abnormal
functioning of vital organs and restrain and control
the nervous system
[19]
.
15.Efficient detoxification- abnormal Doshas,
weakened Dhatus and weakened Agni are major
risk factors which weaken immune status and
predispose an individual to serious diseases such as
cancer. Ama is a toxic, heavy, unctuous, and
sticky juice which originates as a waste-product of
digestion and metabolism
[20]
. The word Amacan
be translated to mean “immature” or “incompletely
digested” food. Amabuilds up in persons whose
digestion is either weak or overloaded with the
wrong foods
[21]
. Individuals with weak Agni (
digestive power) have weak digestive powers (a
characteristic associated with Kapha Prakriti) and
produce Ama more easily. Ayurveda states that
simple foods ( Laghu Ahar) minimize formation of
Ama”. Consuming food or water before complete
digestion of previously consumed food also causes
Ama and leads to vitiation of all three Doshas.
Overall, a weakened Agni is the root cause of
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Ama,” which is a major risk factor for disease
[22]
.
Since “Ama” is considered the root cause of
disease, it must be fully digested before one can
rectify vitiated Doshas
[23]
. Accordingly of 10 types
[24]
. Panchakarma is also a kind of Langhan so
Panchakarma procedures for eliminating vitiated
Doshas are only effective if preexisting Amahas
been completely digested
[25]
. Regular Panchkarma
leads to detoxification and reduces free radicals
which is one of cause of cancer.
16.Dharan (suppression) of Adharniyavega is the
cause of all disease
[26]
, it leads to Vatprakopa. Vata
is responsible for all kinds of action in body, even
accumulation of Vata leads to immflammation
[27]
.
This inflammation give rise to tumors and cancers
[28]
.
16.Cancer is a Santarpanothvyadhi and to get rid of
it one has to follow Langhan. Cause of oxidative
stress is Aam’ which occurs due to Mandagni.
Hence Langhan or fasting (type of Langhan which
means there should be at least 12 hours gap
between two meals) is one of the preventive
remedies for cancer. A study shows fasting causes
autophagy. During fasting the cells break down
proteins and use them for energy
[29]
.
17.Harmonizing the life forces- Ayurveda has
described Ashwasan and Harshanchikitsa or
Satwawjaychikitsa for physical and mental well
being as these makes Pranprasanna (soul happy)
[30]
.
Conclusion :
The causes of cancer enlisted earlier can be
prevented by following preventive measures
mentioned in Ayurveda like :
1) To follow Dincharya, Ritucharya and Sadvritta
(code and conduct), one should not supress
(Dharan) the Adharniya Vega.
2) Always keep mind under control (Dharana of
Dharniya Vega).
3) Undergo Vaman, Virechan, Rakttamokshan
(bloodletting) and Basti in their Prakop Kal
(aggravated time) means Vaman in Vasant
Ritu, Virechan and Rakttamokshan in Sharad
Ritu, and
Basti in Varsha Ritu. After doing
Panchakarma one should take Rasayan and
Vajikaran treatment.
4) Always take healthy diet and do regular
exercise including yoga and pranayama.
5) Take Harshan and Ashwasan Chikittsa to
hormonise inner force. These are preventive
measures of not only cancer but all kind of
diseases.
References:
1. WHO. Health for All, Sr. No. I, 1978.
2. Bouayed, J.; Bohn, T. Exogenous antioxidants-
Double-edged swords in cellular redox state:
Health beneficial effects at physiologic doses
versus deleterious effects at high doses. Oxid.
Med. Cell. Longev. 2010, 3, 228237.
[CrossRef] [PubMed]
3. sahadeo Prasad, sanjay k.shrivastav. oxidative
stress and cancer: chemopreventive and
therapeutic role of Triphala, Antioxidants
2020, 9, 72
4. Anand, P.; Kunnumakkara, A.B.; Sundaram,
C.; Harikumar, K.B.; Tharakan, S.T.; Lai, O.S.;
Sung, B.; Aggarwal, B.B. Cancer is a
preventable disease that requires major lifestyle
changes. Pharm. Res. 2008, 25, 20972116.
5. Huang, C.Y.; Ju, D.T.; Chang, C.F.; Reddy,
P.M.; Velmurugan, B.K. A review on the
effects of current chemotherapy drugs and
natural agents in treating non-small cell lung
cancer. Biomedicine 2017, 7, 1223.
[PubMed]
6. Saylee Deshmukh, Mahesh K. Vyas, R. R.
Dwivedi, and Hitesh A. Vyas. A randomized
open-label comparative clinical study of effect
of lifestyle modification and Shatapushpadya
Churna on Agnimandya, Ayu. 2016, 37(1): 45
55.
7. Kushwaha HC, editor. Acharya Charaks’
Charak Samhita. Pratham Bhag, Varanasi:
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5
Chowkhamba Orientalia; 2009.
8. Tripathi B, editor. Acharya Charkas’ Charak
Samhita. Varanasi: Chowkhamba Surbharati
Prakashan; 2007.
9. Imran A. Khan, Kavita Baranwal, Hari Shankar
Joshi, Pratyush Sharma, Prevention and
management of chronic Non Communicable
Diseases with integrated Modern & Ayurvedic
principles, Indian Journal of Preventive Social
Medicine, 2021, Vol. 52, No. 1.
10. Gupta Atridev, Ashtang Hridayam of
Maharshi Wagbhat with Vidyotini Hindi
commentary, part 1, Sutrasthan 2/20-21,
Varanasi Chaukhamba prakashan, 2008, pg 27
11. Gupta Atridev, Ashtang Hridayam of
Maharshi Wagbhat with Vidyotini Hindi
commentary, part 1, Sutrasthan 2/48, Varanasi
Chaukhamba prakashan, 2008, pg 32
12. Shastri Kashinath Charak Samhita of Agnivesh
revised by Charak and Drudhbala with
Vidyotini commentary, part 1, nidansthan 7/19-
20 Varanasi; Chaukhamba Bharti Academy
Publishers; 2019. p.661.
13. Ashwin Bagde, Ranjeet Sawant, S.U.
Yanpalliwar, Milind Nikumbh, R. S.
Dhimdhime, Ojas: the vital nectar of life,
Journal of Bioloigical and Scientific Opinion
2014, 2 (2).
14. Shastri Kashinath Charak Samhita of Agnivesh
revised by Charak and Drudhba/la with
Vidyotini commentary, part 1, nidansthan 4/52
Varanasi; Chaukhamba Bharti Academy
Publishers; 2019. p.713.
15. Gupta Atridev, Ashtang Hridayam of
Maharshi Wagbhat with Vidyotini Hindi
commentary, part 1, Sutrasthan 11/40, Varanasi
Chaukhamba prakashan, 2008, pg 119
16. Valko, M.; Rhodes, C.J.; Moncol, J.; Izakovic,
M.; Mazur, M. Free radicals, metals and
antioxidants in oxidative stress-induced cancer.
Chem. Biol. Interact. 2006, 160, 140.
[PubMed].
17. Sahadeo Prasad, Sanjay Shrivastav, Oxidative
Stress and Cancer: Chemopreventive and
Therapeutic role of Triphala, Antioxidants,
2020, 9, 72
18. Shyni, G.L.; Ratheesh, M.; Sindhu, G.; Helen,
A. Anti-inflammatory and antioxidant effects
of Jeevaneeya Rasayana: An ayurvedic
polyherbal formulation on acute and chronic
models of inflammation. Immunopharmacol.
Immunotoxicol. 2010, 32, 569575.
19. Imran A. Khan, Kavita Baranwal, Hari Shankar
Joshi, Pratyush Sharma, Prevention and
management of chronic Non Communicable
Diseases with integrated Modern & Ayurvedic
principles, Indian Journal of Preventive Social
Medicine, 2021, Vol. 52, No. 1.
20. Venil Sumantran, Girish Tillu, Cancer,
Inflammation and Insights from Ayurveda,
Evidence Based Complementary & Alternative
Medicine, 2012.
21. J. Mitra, “Ashtanga Samgraha,” Chowkhambha
Sanskrit Series Office, Varanasi, India, pp.
168, 2006.
22. Y.T. Acharya, “Caraka Samhita,” Chaukhamba
Surbharati, Varanasi, India, pp. 525, 1992
23. Y.T. Acharya, “Caraka Samhita,” Chaukhamba
Surbharati, Varanasi, India, pp. 518, 1992.
24. Shastri Kashinath Charak Samhita of Agnivesh
revised by Charak and Drudhbala with
Vidyotini commentary, part 1, sutrasthan 22/18
Varanasi; Chaukhamba Bharti Academy
Publishers; 2019. p.416.
Issue : 03
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Volume : 01
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6
25. J. Mitra, “Ashtanga Samgraha,” Chowkhambha
Sanskrit Series Office, Varanasi, India, pp.
168, 2006.
26. Gupta Atridev, Ashtang Hridayam of Maharshi
Wagbhat with Vidyotini Hindi commentary,
part 1, Sutrasthan 4/21, Varanasi Chaukhamba
Prakashan,2008, pg 46.
27. Shastri Kashinath Charak Samhita of Agnivesh
revised by Charak and Drudhbala with
Vidyotini commentary, part 1, sutrasthan 18/29
Varanasi; Chaukhamba Bharti Academy
Publishers; 2019. p.380.
28. Shastri Kashinath Charak Samhita of Agnivesh
revised by Charak and Drudhbala with
Vidyotini commentary, part 1, chikitsasthan
5/17 Varanasi; Chaukhamba Bharti Academy
Publishers; 2019. p.202.
29. Mohammad Bagherniya, Alexandra E. Butler,
George E. Barreto, Amirhossein Sahebkar, The
effect of fasting or calorie restriction on
autophagy induction: A review of the literature,
Ageing Research Reviews, 2018, vol. 47, pgs.
183- 197.
30. Shastri Kashinath Charak Samhita of Agnivesh
revised by Charak and Drudhbala with
Vidyotini commentary, part 1, chikitsasthan
9/79 Varanasi; Chaukhamba Bharti Academy
Publishers; 2019. p.324.
ISSN : 2584-2757
DOI : 10.5281/zenedo.10972407
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